Induction of Pluripotent Stem Cells from Mouse Embryonic and Adult Fibroblast Cultures by Defined Factors

Kazutoshi Takahashi and Shinya Yamanaka's landmark 2006 Cell paper (126:4) demonstrating that four transcription factors can reprogram adult cells to a pluripotent state — the discovery (Nobel Prize 2012) that founded the induced-pluripotent-stem-cell field and underlies the contemporary cellular-reprogramming longevity trajectory the corpus engages.